Abstract: The pharmacological therapy of presbyopia mainly includes parasympathetic agonists such as carbachol, pilocarpine, presbidrops, etc, which stimulate the contraction of ciliary muscle and enhance the accommodated ability of eye. Lipoic choline sulfate and Liquid Vision could be used to reduce the hardness of the lens, restore the elasticity of the lens and enhance the near vision ability. However, these drugs still have some limits, including working on single factor, unclear mechanism of combined drugs, lack of multi-center research support, and unclear the optimal concentration of the drug combination, long-term efficacy, drug side effects, patient compliance etc. Whether it is necessary to adjust the concentration, frequency and administration time according to the degree of accommodated ability decrease also needs further verification. (Int Rev Ophthalmol, 2020, 44：182-186)